2010年9月20日

[雨果診療室] 免疫及標靶藥物整理

引用自Harrison’s Priciple of Internal Medicine 17th edition

免疫藥物:

Name Mechanism
Entanercept TNF type II receptor fused to IgG1

Infliximab

chimeric mouse/human monoclonal antibody
to TNF

adalimumab fully human antibody to TNF

Anakinra

recombinant IL-1 receptor antagonist that competitively
blocks the binding of IL-1β and IL-1α to the IL-1 receptor and thereby inhibits the activity of these two related proinflammatory cytokines

Rituximab

a chimeric antibody directed to CD20 that depletes mature B cells

batacept

A is a fusion protein consisting of CTLA4 and the Fc portion of IgG1. It
inhibits T cell activation by competitively inhibiting the co-stimulation of T cellsthat results from interaction of T cell–expressed CD28 and CD80/86 expressed by antigen-presenting cells.

標靶藥物:

Name Mehanism Indication

All-trans retinoic acid(ATRA)

PML-RARα oncogene

Acute promyelocytic leukemia M3 AML;
t(15;17)

Imatinib (Gleevec)

Bcr-Abl, c-Abl, c-Kit,
PDGFR-α/β,

Chronic myelogenous leukemia; GIST

Sunitinib (Sutent)

c-Kit, VEGFR-2, PDGFR-β,
Flt-3

GIST; renal cell cancer

Sorafinib (Nexavar)

RAF, VEGFR-2, PDGFR-α/β, Flt-3, c-Kit

RCC; may have activity in melanoma
when combined with chemotherapy

Erlotinib (Tarceva)

EGFR Tki

Non-small cell lung cancer; pancreatic
cancer

Gefitinb (Iressa) EGFR Tki Non-small cell lung cancer
Bortezomib (Velcade) Proteasome Multiple myeloma
    以下為Monoclonal Antibodies

Trastuzumab
(Herceptin)

HER2/neu (ERBB2)

Breast cancer

Cetuximab (Erbitux)

EGFR

Colon cancer, squamous cell carcinoma
of the head and neck

Panitumomab (Vectibix) EGFR Colon cancer

Rituximab (Rituxan)

CD20

B cell lymphomas and leukemias that
express CD20

Alemtuzumab
(Campath)

CD52

Chronic lymphocytic leukemia and
CD52-expressing lymphoid tumors

Bevacizumab (Avastin)

VEGF

Colon, lung, breast cancers; data
pending in other tumors

要看中文版的這篇還不錯:http://www.raag.org.tw/menu4_1.php?a_id=63

1 則留言:

  1. Yoli Su Panitumumab 和 Alemtuzumab可以不用記(台灣沒有)
    倒是可能要記得Dasatinib and Nilotinib...在CML的data better than Glivec

    回覆刪除

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